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Immunological Fluctuations During Intrathecal Immunotherapy in Three Patients Affected by CNS Tumours Disseminating Via CSF by A. Salmaggi; A. Dufour; A. Silvani; E. Ciusani; A. Nespolo; A. Boiardi is a Neuroscience article available to read on EtoBox.
What is Immunological Fluctuations During Intrathecal Immunotherapy in Three Patients Affected by CNS Tumours Disseminating Via CSF about?
The immunological therapy of cancer has been proposed in a number of neoplasms (Borden, Sondel, 1989; Foon, 1989; Rosenberg, 1992) and has recently been adopted in the treatment of Central Nervous System (CNS) tumors in combination with conventional surgical and radiotherapeutical approach. In this context, loco-regional administration of immunomodulating agents (for instance in post-surgical cavity) allows to achieve much higher in situ concentrations than by systemic route. Since these treatments have potential adverse effects, careful assessment of clinical and immunological parameters in phase I trials is needed. CNS tumors disseminating via Cerebrospinal Fluid (CSF) pathways offer a stimulating opportunity for intrathecal immunotherapy. In this context, alpha-IFN and IL2 (alone or in combination with LAK cells) have been employed either loco-regionally or intrathecally (Merchant, Mc Vicar, Merchant & Young, 1992; Schiller, Hank, Storer, Borchert, Moore, Albertini, Bechhofer, Wesley, Brown, Bastin & Sondel, 1993). The rationale for the use of both these substances includes the known anti-tumor action of alpha-IFN (Mahaley, Urso, Whaley, Blue, Williams, Guaspari & Selker, 1985;
Who reads Immunological Fluctuations During Intrathecal Immunotherapy in Three Patients Affected by CNS Tumours Disseminating Via CSF?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- A. Salmaggi; A. Dufour; A. Silvani; E. Ciusani; A. Nespolo; A. Boiardi
- Publisher
- Informa UK Limited
- Published
- 1994
- Language
- EN
- Field
- Neuroscience (Life Sciences)