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Yiqi Huayu Jiedu Decoction inhibits liver metastasis of colorectal cancer via enhancing natural killer cells function by Jin-Yong Zhou; Cunen Wu; Zhaofeng Shen; Shenlin Liu; Xi Zou; Jun Qian; Zhenfeng Wu; Xiangkun Huan; Bai-Xiang Mu; Ningyuan Ye; Yongbo Ning; Yaxing Wang; Min Chen; Yuwen Zhuang is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Yiqi Huayu Jiedu Decoction inhibits liver metastasis of colorectal cancer via enhancing natural killer cells function about?
Ethnopharmacological relevance: Complementary treatment with valuable efficacy and less toxic or side effect is in urgent need for colorectal cancer (CRC) therapy. Yiqi Huayu Jiedu Decoction (YHJD) is a polyherbal formulation which has been applied in clinic to treat CRC for a long period of time. Nevertheless, the potential active ingredients and molecular mechanism remains to be further explored. ## Aim of the study: To probe the effective compounds of YHJD and its underlying pharmacological effects. Moreover, the influence on liver metastasis of CRC as well as function of natural killer (NK) cells results from YHJD was investigated. Materials and methods: The active ingredients and target genes of YHJD was examined through TCMSP databases. Compound-compound target network was performed by applying Cytoscape3.9.1 software. The CRC-related disease targets were explored via DisGeNET database. Venn database was used to find the common genes between CRC and YHJD. Protein-protein interaction network was established by STRING database. Biological process and signaling pathways potentially regulated by YHJD were evaluated by DAVID database. Western blot assay was then conducted to furth
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It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Jin-Yong Zhou; Cunen Wu; Zhaofeng Shen; Shenlin Liu; Xi Zou; Jun Qian; Zhenfeng Wu; Xiangkun Huan; Bai-Xiang Mu; Ningyuan Ye; Yongbo Ning; Yaxing Wang; Min Chen; Yuwen Zhuang
- Publisher
- Elsevier BV
- Published
- 2024
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)