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The document discusses using acetic anhydride to derivatize biogenic amines and psychiatric drugs for analysis by gas chromatography and mass spectrometry. It can derivatize amines and phenols under aqueous conditions and all three functional groups under anhydrous conditions, improving extraction and detection. Examples are given of analyzing compounds like phenylethylamine, serotonin, and tryptamine from tissues and drugs using acetic anhydride derivatization followed by another derivatization.

Author

Leo Esposito

Language

EN