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Clinicopathologic features of patients with hepatocellular carcinoma seropositive for α-fetoprotein-L3 and seronegative for des-γ-carboxy prothrombin in comparison with those seropositive for des-γ-carboxy prothrombin alone by HIROAKI OKUDA; TOSHIMI NAKANISHI; KAZUKO TAKATSU; AKIKO SAITO; NAOAKI HAYASHI; MASAKAZU YAMAMOTO; KEN TAKASAKI; MASAYUKI NAKANO is a Medicine article available to read on EtoBox.

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**Abstract****__Background__ :** There has been no study of the clinicopathologic features of patients with hepatocellular carcinoma (HCC) who are seropositive for lectin‐reactive α‐fetoprotein (AFP‐L3) alone, or seropositive for AFP‐L3 and seronegative for des‐γ‐carboxy prothrombin (DCP) in comparison with those who are seropositive for DCP alone. Thus, the present comparative study was performed. **__Methods__ :** The clinicopathologic features of HCC patients with either one or two tumors who underwent a hepatectomy (__n__ = 88) were compared among the following five groups according to the seropositivity of AFP, AFP‐L3 and DCP: (i) group A, seropositive for AFP above 100 ng/mL, AFP‐L3 above 15% and DCP above 100 mAU/mL; (ii) group B, seropositive for AFP‐L3 and seronegative for DCP below 40 mAU/mL; (iii) group C, seronegative for AFP below 20 ng/mL, AFP‐L3 below 15% and seropositive for DCP; (iv) group D, seropositive for AFP and seronegative for AFP‐L3 and DCP; and (v) group E, seronegative for AFP, AFP‐L3 and DCP. **__Results__ :** Group B patients showed a higher incidence of infiltrative‐type HCC with an irregular margin (__P__ < 0.05) and a higher frequency of poorly di

Who reads Clinicopathologic features of patients with hepatocellular carcinoma seropositive for α-fetoprotein-L3 and seronegative for des-γ-carboxy prothrombin in comparison with those seropositive for des-γ-carboxy prothrombin alone?

Author

HIROAKI OKUDA; TOSHIMI NAKANISHI; KAZUKO TAKATSU; AKIKO SAITO; NAOAKI HAYASHI; MASAKAZU YAMAMOTO; KEN TAKASAKI; MASAYUKI NAKANO

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0815-9319)

Published

2002

Language

EN

Field

Medicine (Health Sciences)