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This document discusses the discovery of small-molecule antibiotics targeting a unique tRNA-mediated transcription regulation mechanism in Gram-positive bacteria, specifically the T-box system. The study highlights the potential of these compounds, such as PKZ18, to inhibit bacterial growth without inducing resistance, offering a new avenue for antibiotic development against drug-resistant strains. The findings suggest that targeting the T-box regulatory mechanism could be a promising strategy in combating
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- gohkaiyun1
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- EN