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A Novel Method of Peritoneal Resuscitation Improves Organ Perfusion After Hemorrhagic Shock by El Rasheid Zakaria; Ryan T Hurt; Paul J Matheson; R.Neal Garrison is a Medicine article available to read on EtoBox.

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Background: After resuscitation from hemorrhagic shock, intestinal microvessels constrict leading to impairment of blood flow. This occurs despite restoration and maintenance of central hemodynamics. Our recent studies have demonstrated that topical and continuous exposure of the gut microvasculature to a clinical solution (Delflex; Fresenius Medical Care), as a technique of direct peritoneal resuscitation (DPR), reverses the postresuscitation vasoconstriction and hypoperfusion to a sustained dilation and hyperperfusion. We hypothesize that initiation of DPR simultaneously with resuscitation from hemorrhagic shock enhance organ blood flow to all tissues surrounding the peritoneal cavity as well as distant organs. Methods: Male Sprague-Dawley rats were anesthetized, intubated and cannulated for monitoring of hemodynamics and for withdrawal of blood. Rats were hemorrhaged to 50% of mean blood pressure for 60 minutes prior to resuscitation with shed blood plus 2 volumes of saline. Animals were randomized for intraperitoneal therapy with 30 mL saline (group 1, n ϭ 9), or Delflex (group 2, n ϭ 9). Whole organ blood flow was measured by colorimetric microsphere technique with phantom org

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Author

El Rasheid Zakaria; Ryan T Hurt; Paul J Matheson; R.Neal Garrison

Publisher

Elsevier BV

Published

2003

Language

EN

Field

Medicine (Health Sciences)