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Primidone-loaded Poly-ε-caprolactone Nanocapsules: Incorporation Efficiency and in Vitro Release Profiles by V Ferranti; H Marchais; C Chabenat; A.M Orecchioni; O Lafont is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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This paper describes the preparation of primidone-loaded poly-o-caprolactone nanocapsules according to the interfacial deposition technique. The colloidal suspension obtained showed a monomodal size distribution with a mean diameter ranging from 308 to 352 nm. By adjusting the process parameters, the encapsulation efficiency was about 74% with good reproducibility. Primidone release from the nanocapsules was found to be slower as compared to the oily control solution despite an important burst-effect. The release profile was not influenced by the pH of the release medium.

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Author

V Ferranti; H Marchais; C Chabenat; A.M Orecchioni; O Lafont

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

1999

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)