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Can I read Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial on EtoBox?
Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial by Daisuke Morishita; Toshihiko Tomita; Sumire Mori; Takeshi Kimura; Tadayuki Oshima; Hirokazu Fukui; Hiroto Miwa is a Medicine article available to read on EtoBox.
What is Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial about?
## INTRODUCTION: This is the first prospective, double-blinded, randomized, placebo-controlled trial to evaluate the safety and efficacy of a stimulant laxative compared with an osmotic agent for the treatment of chronic idiopathic constipation. ## METHODS: Patients were randomly administered stimulant laxative (senna, 1.0 g), osmotic agent (magnesium oxide [MgO], 1.5 g), or placebo for 28 consecutive days. The primary endpoint was overall symptom improvement. Secondary endpoints were spontaneous bowel movement (SBM), complete SBM, and patient assessment of constipation quality of life (QOL). ## RESULTS: Ninety patients (mean age, 42 years; 93% women; mean duration of symptoms, 9.9 years) were enrolled; all completed the study. The response rate for overall improvement was 11.7% in the placebo group, 69.2% in the senna group, and 68.3% in the MgO group (P < 0.0001). Change in SBM was significantly greater in the senna and MgO groups than that in the placebo group (P < 0.001). Similarly, change in complete SBM was significantly greater in the senna and MgO groups than that in the placebo group (P < 0.01). On the patient assessment of constipation QOL, significant improvements were s
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- Author
- Daisuke Morishita; Toshihiko Tomita; Sumire Mori; Takeshi Kimura; Tadayuki Oshima; Hirokazu Fukui; Hiroto Miwa
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)