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Preliminary Results in the Treatment of Recurrent Non-small Cell Lung Cancer (NSCLC) with Stereotactic Body Radiation Therapy (SBRT): Does Total Dose and Tumor Volume Impact Local Control? by Costello, J.E.; Finnerty, E.P.; Deming, R.L.; Strom, D.K.; Bernstein, K.J.; Bellville, N.J.; Burgin, C.M.; Jacobsen, R.P.; Puri, D.R. is a Medicine article available to read on EtoBox.

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Purpose/Objective(s): Recently published results of RTOG 0236 highlight outstanding local control (LC) rates when SBRT is used for inoperable early-stage NSCLC. However, data concerning efficacy and safety of SBRT for recurrent NSCLC remains limited. The main purpose of this retrospective study was to identify treatment and tumor characteristics that might predict for better LC when SBRT is employed for solitary pulmonary recurrences. We also report on short-and intermediate-term toxicities in this cohort of patients, many of whom received prior thoracic radiotherapy (TRT). Materials/Methods: From 4/05-7/09, 28 patients with recurrent NSCLC were treated with SBRT using a robotic system (CyberKnife, Accuray, Sunnyvale, CA) with fiducial-based respiratory tracking. All recurrences were biopsy-proven and/or PET-avid (SUV$4.5) solitary lesions. Median SBRT dose was 48Gy (range: 24-60 Gy in 3-5 fractions), with treatment margins (GTV-to-PTV) of 0-5 mm. Median GTV was 21cc (range: 2-83cc). Seventy-five percent of patients received prior TRT for their primary NSCLC. Median time between TRT and SBRT was 29 months (range: 7-113 months). Toxicities were scored by the RTOG criteria. Results:

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Author

Costello, J.E.; Finnerty, E.P.; Deming, R.L.; Strom, D.K.; Bernstein, K.J.; Bellville, N.J.; Burgin, C.M.; Jacobsen, R.P.; Puri, D.R.

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2010

Language

EN

Field

Medicine (Health Sciences)