About this document
Liver by JericSalcedo is a document available to read on EtoBox.
Drug metabolism involves converting drugs into more polar, excretable compounds through Phase I and Phase II reactions. Phase I introduces functional groups like OH, COOH, NH2 through oxidation, reduction, and hydrolysis. Phase II conjugates these functional groups with endogenous compounds like glucuronic acid and sulfate. The liver is a major site of drug metabolism. Metabolism can activate prodrugs, change pharmacological effects, or produce toxic compounds. Certain enzymes like CYP2D6 are important for
- Author
- JericSalcedo
- Language
- EN