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Spinal motor neuron neuroaxonal spheroids in chronic aluminum neurotoxicity contain phosphatase-resistant high molecular weight neurofilament (NFH) by S. Gaytan-Garcia; Harold Kim; M.J. Strong is a Environmental Science article available to read on EtoBox.

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It has previously been shown that a single intracistemal inoculum of AlCl, in young adult New Zealand white rabbits will induce a dose-dependent phosphatase resistance of the high molecular weight neurofilament protein (NFH) that is proportionate to the extent of neurofilamentous inclusion formation (Strong and Jakowec, 1994). To determine if the potential for dissolution of aluminum-induced neurotilamentous inclusions was dependant on the degree of NFH phosphatase resistance, we have examined NFH phosphatase sensitivity in a reversible chronic model of aluminum neurotoxicity. Rabbits receiving repeated intracistemal inoculums of 100 fig AlCl, at 28 day intervals until day 267 develop spinal motor neuron perikaryal and neuroaxonal neurofilamentous aggregates in a stereotypic, dosedependent fashion. In the rabbits receiving inoculums until day 156 with survival until day 267 without further aluminum exposure, neuroaxonal spheroids remained prominent while perikaryal inclusions largely resolved. Immunoreactivity to a monoclonal antibody recognizing phosphorylated NFH (SMI 31) was abolished in perikaryal aggregates at each time interval by dephosphorylation with bovine alkaline phosph

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Author

S. Gaytan-Garcia; Harold Kim; M.J. Strong

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)

Published

1996

Language

EN

Field

Environmental Science (Life Sciences)