Opening book details…
Can I read Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma on EtoBox?
Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma by Masayoshi Nagata; Mika Sakurai-Yageta; Daisuke Yamada; Akiteru Goto; Akihiko Ito; Hiroshi Fukuhara; Haruki Kume; Teppei Morikawa; Masashi Fukayama; Yukio Homma; Yoshinori Murakami is a Medicine article available to read on EtoBox.
What is Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma about?
## Abstract Renal clear cell carcinoma (RCCC) is the most frequent subpopulation of renal cell carcinoma and is derived from the proximal uriniferous tubules. We have previously reported that an actin‐binding protein, 4.1B/DAL‐1, is expressed in renal proximal tubules, whereas it is inactivated in 45% of RCCC by promoter methylation. In the lung and several epithelial tissues, 4.1B is shown to associate with a tumor suppressor protein, CADM1, belonging to the immunoglobulin‐superfamily cell adhesion molecules. Here, we demonstrate by immunohistochemistry that another member of the CADM‐family protein, CADM4, as well as 4.1B is expressed specifically in human proximal tubules, while CADM1 and 4.1N, another member of the 4.1 proteins, are expressed in the distal tubules. Immunoprecipitation analysis coupled with Western blotting revealed that CADM4 associated with 4.1B, while CADM1 associated with 4.1N in the lysate from normal human kidney, implicating that a cascade of CADM4 and 4.1B plays an important role in normal cell adhesion of the proximal tubules. On the other hand, CADM4 expression was lost or markedly reduced in 7 of 10 (70%) RCC cell lines and 28 of 40 (70%) surgically r
Who reads Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Masayoshi Nagata; Mika Sakurai-Yageta; Daisuke Yamada; Akiteru Goto; Akihiko Ito; Hiroshi Fukuhara; Haruki Kume; Teppei Morikawa; Masashi Fukayama; Yukio Homma; Yoshinori Murakami
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)