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Can I read Diacetylrhein, an anthraquinone antiarthritic agent, suppresses dextran sodium sulfate-induced inflammation in rats: A possible mechanism for a protective effect against ulcerative colitis on EtoBox?
Diacetylrhein, an anthraquinone antiarthritic agent, suppresses dextran sodium sulfate-induced inflammation in rats: A possible mechanism for a protective effect against ulcerative colitis by Mona H. Zohny; Mohammed Alrouji; Sharif Alhajlah; Othman AlOmeir; Mohamed Gamal El-Din Ewees; Dalia M. Abdel Ghaffar; Noura El Adle Khalaf; Osama A. Mohammed; Mahmoud Said Ibrahim Abdeldaiem; Waleed Barakat El-Bahouty; Amr Elrabat; Sahar Zakaria; Zeinab M. Abdel-Nasser; Amira A. Haleem; Doaa M. El-Gharbawy; Rasha Abdelhady; Mohamed M.Y. Kaddah; Ahmed Shata; Sameh Saber is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Diacetylrhein, an anthraquinone antiarthritic agent, suppresses dextran sodium sulfate-induced inflammation in rats: A possible mechanism for a protective effect against ulcerative colitis about?
Ulcerative colitis (UC) is a chronic inflammatory life-threatening and premalignant disorder with no cure that even might end up with surgical removal of a large section or even all of the colon. It is characterized by relapsing-remitting courses of intestinal inflammation and mucosal damage in which oxidative stress and exaggerated inflammatory response play a significant role. Most of the current medications to maintain remission are symptomatic and have many adverse reactions. Therefore, the potential for improved management of patients with UC continues to increase. Yet, the benefits of using the antiarthritic agent diacetylrhein to counteract inflammation in UC are still obscure. Hence, our study was designed to explore its potential role in UC using a model of dextran sodium sulfate-induced acute colitis in rats. Our results revealed that diacetylrhein targeted the NLRP3 and inhibited the inflammasome assembly. Consequently, caspase-1 activity and the inflammatory cytokines IL-1β and IL-18 were inhibited leading to a curbed pyroptosis process. Additionally, diacetylrhein revealed a significant antiapoptotic potential as revealed by the levels of pro-apoptotic and anti-apoptot
Who reads Diacetylrhein, an anthraquinone antiarthritic agent, suppresses dextran sodium sulfate-induced inflammation in rats: A possible mechanism for a protective effect against ulcerative colitis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Mona H. Zohny; Mohammed Alrouji; Sharif Alhajlah; Othman AlOmeir; Mohamed Gamal El-Din Ewees; Dalia M. Abdel Ghaffar; Noura El Adle Khalaf; Osama A. Mohammed; Mahmoud Said Ibrahim Abdeldaiem; Waleed Barakat El-Bahouty; Amr Elrabat; Sahar Zakaria; Zeinab M. Abdel-Nasser; Amira A. Haleem; Doaa M. El-Gharbawy; Rasha Abdelhady; Mohamed M.Y. Kaddah; Ahmed Shata; Sameh Saber
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)