About this Biochemistry, Genetics and Molecular Biology article

Repair of Airway Epithelia Requires Metabolic Rewiring Towards Fatty Acid Oxidation by Stefania Crotta; Matteo Villa; Jack Major; Katja Finsterbusch; Miriam Llorian; Peter Carmeliet; Joerg Buescher; Andreas Wack is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

## Abstract Epithelial tissues provide front-line barriers shielding the organism from invading pathogens and harmful substances. In the airway epithelium, the combined action of multiciliated and secretory cells sustains the mucociliary escalator required for clearance of microbes and particles from the airways. Defects in components of mucociliary clearance or barrier integrity are associated with recurring infections and chronic inflammation. The timely and balanced differentiation of basal cells into mature epithelial cell subsets is therefore tightly controlled. While different growth factors regulating progenitor cell proliferation have been described, little is known about the role of metabolism in these regenerative processes. Here we show that basal cell differentiation correlates with a shift in cellular metabolism from glycolysis to fatty acid oxidation (FAO). We demonstrate both in vitro and in vivo that pharmacological and genetic impairment of FAO blocks the development of fully differentiated airway epithelial cells, compromising the repair of airway epithelia. Mechanistically, FAO links to the hexosamine biosynthesis pathway to support protein glycosylation in airwa

Author

Stefania Crotta; Matteo Villa; Jack Major; Katja Finsterbusch; Miriam Llorian; Peter Carmeliet; Joerg Buescher; Andreas Wack

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)