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A visual rating scale for cingulate island sign on 18F-FDG-PET to differentiate dementia with Lewy bodies and Alzheimer's disease by Le Gjerum; Kristian Steen Frederiksen; Otto Mølby Henriksen; Ian Law; Lasse Anderberg; Birgitte Bo Andersen; Eva Bjerregaard; Anne-Mette Hejl; Peter Høgh; Steen Gregers Hasselbalch is a Medicine article available to read on EtoBox.

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Valid diagnosis of dementia with Lewy bodies (DLB) is essential to establish appropriate treatment and care. However, the diagnostic accuracy is complicated by clinical and pathological overlap with Alzheimer's disease (AD). Cingulate island sign (CIS), defined as sparing of posterior cingulate cortex (PCC) relative to precuneus and cuneus on 18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET), is included in the revised diagnostic DLB criteria. There are no guidelines for the visual grading of CIS, although visual rating is a fastapplicable method in a clinical setting. The objective was to develop a robust visual CIS scale and evaluate the performance in differentiating DLB with and without amyloid beta pathology (Aβ+/-), and AD. 18F-FDG-PET scans from 35 DLB patients, 36 AD patients, and 23 healthy controls were rated according to a visual CIS scale based on specific reading criteria. The visual CIS scale was validated against a quantitative CIS ratio derived from a region of interest analysis of PCC, precuneus, and cuneus. DLB patients had a significantly higher visual CIS score compared to AD patients, and controls. A cut-off visual CIS score of 4 significantly

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Author

Le Gjerum; Kristian Steen Frederiksen; Otto Mølby Henriksen; Ian Law; Lasse Anderberg; Birgitte Bo Andersen; Eva Bjerregaard; Anne-Mette Hejl; Peter Høgh; Steen Gregers Hasselbalch

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0022-510X)

Published

2020

Language

EN

Field

Medicine (Health Sciences)