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The factor V Leiden mutation in children with cancer and thrombosis by Maria T. Sifontes; Rachelle Nuss; Stephen P. Hunger; Judith Wilimas; Linda J. Jacobson; Marilyn J. Manco‐Johnson is a Medicine article available to read on EtoBox.

What is The factor V Leiden mutation in children with cancer and thrombosis about?

Thromboembolic phenomena, frequently observed in children with cancer who are undergoing chemotherapy, can cause significant morbidity and, less frequently, mortality. Many contributory factors have been identified. Whether the recently identified and most common coagulation defect predisposing to thrombosis, factor V Leiden, is associated with thrombosis in this setting, has not been explored. The current study was undertaken to determine the prevalence of the factor V Leiden mutation in children with cancer who developed thromboembolic phenomena as compared to those with cancer who did not. Genomic DNA was amplified using the polymerase chain reaction (PCR), followed by digestion of the amplification product with the restriction enzyme __Mnl__I. The digested PCR products were then size‐fractionated to classify samples as heterozygous, homozygous or normal for the factor V Leiden mutation. 67 children with cancer were evaluated for the factor V Leiden mutation. One of 32 children with cancer and thrombosis, and none of 35 who had not experienced thrombotic problems, was found heterozygous for this mutation. We conclude that the factor V Leiden mutation does not play a significant

Who reads The factor V Leiden mutation in children with cancer and thrombosis?

Author

Maria T. Sifontes; Rachelle Nuss; Stephen P. Hunger; Judith Wilimas; Linda J. Jacobson; Marilyn J. Manco‐Johnson

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

1997

Language

EN

Field

Medicine (Health Sciences)