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Can I read BDDE-Inspired Chalcone Derivatives to Fight Bacterial and Fungal Infections on EtoBox?
BDDE-Inspired Chalcone Derivatives to Fight Bacterial and Fungal Infections by Ana Jesus; Fernando Durães; Nikoletta Szemerédi; Joana Freitas-Silva; Paulo Martins da Costa; Eugénia Pinto; Madalena Pinto; Gabriella Spengler; Emília Sousa; Honorina Cidade is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is BDDE-Inspired Chalcone Derivatives to Fight Bacterial and Fungal Infections about?
The growing number of infectious diseases around the world threatens the effective response of antibiotics, contributing to the increase in antibiotic resistance seen as a global health problem. Currently, one of the main challenges in antimicrobial drug discovery is the search for new compounds that not only exhibit antimicrobial activity, but can also potentiate the antimicrobial activity and revert antibiotics’ resistance, through the interference with several mechanisms, including the inhibition of efflux pumps (EPs) and biofilm formation. Inspired by macroalgae brominated bromophenol BDDE with antimicrobial activity, a series of 18 chalcone derivatives, including seven chalcones (**9**–**15**), six dihydrochalcones (**16**–**18**, and **22**–**24**) and five diarylpropanes (**19**–**21**, and **25** and **26**), was prepared and evaluated for its antimicrobial activity and potential to fight antibiotic resistance. Among them, chalcones **13** and **14** showed promising antifungal activity against the dermatophyte clinical strain of __Trichophyton rubrum__, and all compounds reversed the resistance to vancomycin in __Enterococcus faecalis__ B3/101, with **9**, **14**, and **24
Who reads BDDE-Inspired Chalcone Derivatives to Fight Bacterial and Fungal Infections?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ana Jesus; Fernando Durães; Nikoletta Szemerédi; Joana Freitas-Silva; Paulo Martins da Costa; Eugénia Pinto; Madalena Pinto; Gabriella Spengler; Emília Sousa; Honorina Cidade
- Publisher
- MDPI AG
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)