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Studies on the application of the Passerini reaction and enzymatic procedures to the synthesis of tripeptide mimetics by Wiktor Szymanski; Magdalena Zwolinska; Ryszard Ostaszewski is a Chemistry article available to read on EtoBox.

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A new, efficient method for the multicomponent synthesis of tripeptide mimetics is presented. Simple, chemoenzymatic transformations of Passerini reaction products enable the introduction of varied amino acid moieties into the tripeptide scaffold, with control of the stereochemistry. Additionally, this method allows the convenient introduction of a methyl group to the amide nitrogen, leading to derivatives of N-methylated amino acids-compounds of interest for medicinal chemistry.

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Author

Wiktor Szymanski; Magdalena Zwolinska; Ryszard Ostaszewski

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4020)

Published

2007

Language

EN

Field

Chemistry (Physical Sciences)