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Can I read Liraglutide Abrogates Nephrotoxic Effects of Chemotherapies on EtoBox?
Liraglutide Abrogates Nephrotoxic Effects of Chemotherapies by Cong Xu; Chenqi Lu; Zhimin Wang; Xiaofan Hu; Shanglin Li; Yanan Xie; Yang Qiu; Rui Cao; Yakun Li; Jun Yang is a Medicine article available to read on EtoBox.
What is Liraglutide Abrogates Nephrotoxic Effects of Chemotherapies about?
Acute kidney injury (AKI) is a common clinical complication. Cisplatin (Cis) is an effective chemotherapeutic drug; however, its acute nephrotoxicity often limits its application. The role of liraglutide (Lir), an agonist of the glucagon-like peptide-1 receptor (GLP-1R), has recently attracted increasing attention beyond glycemic regulation. This study showed that Lir significantly ameliorated Cis-induced kidney dysfunction and renal damage. However, this renoprotective effect was partially abolished in GLP-1R knockout (GLP-1R-/-) mice. Furthermore, we synthesized Lir metabolites, GLP-1 (9−37) and GLP-1 (28−37), and found that they also exerted reno-protective effects that were not impaired in GLP-1R-/- mice. We also demonstrated that Lir and its metabolites reduced cisplatin-induced apoptosis in human renal tubular epithelial cells (HK-2). After silencing GLP-1R expression in HK-2 cells with small interfering ribose nucleic acid (siRNA), the protective effect of Lir on HK-2 cells was inhibited, while the protective effects of GLP-1 (9−37) and GLP-1 (28−37) were not affected. Additionally, we demonstrated that Lir and its metabolites inhibited Cis-induced high-mobility group box 1
Who reads Liraglutide Abrogates Nephrotoxic Effects of Chemotherapies?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Cong Xu; Chenqi Lu; Zhimin Wang; Xiaofan Hu; Shanglin Li; Yanan Xie; Yang Qiu; Rui Cao; Yakun Li; Jun Yang
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Life Sciences)