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Can I read Genetic approaches in the clinical investigation of complex disorders: Malnutrition, inflammation, and atherosclerosis (MIA) as a prototype on EtoBox?
Genetic approaches in the clinical investigation of complex disorders: Malnutrition, inflammation, and atherosclerosis (MIA) as a prototype by Roberto Pecoits-Filho; Louise Nordfors; Bengt Lindholm; Catherine M. Hoff; Martin Schalling; Peter Stenvinkel is a Medicine article available to read on EtoBox.
What is Genetic approaches in the clinical investigation of complex disorders: Malnutrition, inflammation, and atherosclerosis (MIA) as a prototype about?
Despite major research efforts and improvements in dialysis technology, patients with end-stage renal disease (ESRD) experience an extremely high mortality, which seems to be increasingly related to cardiovascular disease. Cardiovascular disease has been linked to the presence of systemic inflammation and malnutrition (MIA syndrome), in addition to the high prevalence of traditional risk factors observed in ESRD patients. Since the mechanisms underlying the development of these complications of ESRD are largely unknown, new strategies for identification of risk factors, pathophysiologic pathways, and targets for intervention are warranted. Although the combined impact of MIA complications seems to determine the extremely poor clinical outcome in the ESRD patients, there are significant unexplained individual differences in the development of the MIA syndrome, implying that genetic differences might play a role. The vast information generated by the advances in molecular genetics offers a great opportunity to analyze the causes of differences not only in our susceptibility to (or protection from) various diseases, but also in the age of onset, severity of illness, and in the way our
Who reads Genetic approaches in the clinical investigation of complex disorders: Malnutrition, inflammation, and atherosclerosis (MIA) as a prototype?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Roberto Pecoits-Filho; Louise Nordfors; Bengt Lindholm; Catherine M. Hoff; Martin Schalling; Peter Stenvinkel
- Publisher
- Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; ScienceOpen (ISSN 0085-2538)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)