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Can I read Antiandrogenic effect of crude extract of C-heavy oil on EtoBox?
Antiandrogenic effect of crude extract of C-heavy oil by Ryoichi Kizu; Katsuaki Ishii; Jun Kobayashi; Takuma Hashimoto; Eitetsu Koh; Mikio Namiki; Kazuichi Hayakawa is a Engineering article available to read on EtoBox.
What is Antiandrogenic effect of crude extract of C-heavy oil about?
An oil spill accident happened to a Russian tanker Nakhodka with a cargo of heavy oil type C in the Sea of Japan on January, 1997 and the spilled oil severely polluted the coast of Japan and damaged the environment. In this study, androgenic and antiandrogenic activities of C-heavy oil crude extracts prepared with ethanol were evaluated on two androgen-responsive cell lines, a Shionogi mouse mammary carcinoma SC115 and a human prostate carcinoma LNCaP. Oils used in this study were the Nakhodka and a commercial Ž . C-heavy oils. Assessment of androgenic and antiandrogenic activities was made on the basis of effect on proliferation SC115 and Ž . Ž . Ž . prostate specific antigen PSA production LNCaP cells in the absence and the presence of 0.5 nM dihydrotestosterone DHT . While both extracts exerted almost no effect on the proliferation and PSA production of SC115 and LNCaP cells in the absence of DHT, the extracts significantly inhibited the DHT-induced proliferation and PSA production of the cells in the presence of DHT, indicating that the Ž . C-heavy oils contains antiandrogenic compounds. It has been known that androgen receptor AR expressed in LNCaP cells has mutation in ligand
Who reads Antiandrogenic effect of crude extract of C-heavy oil?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Ryoichi Kizu; Katsuaki Ishii; Jun Kobayashi; Takuma Hashimoto; Eitetsu Koh; Mikio Namiki; Kazuichi Hayakawa
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0928-4931)
- Published
- 2000
- Language
- EN
- Field
- Engineering (Physical Sciences)