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Impact of the Initial Decline in Estimated Glomerular Filtration Rate on the Risk of New‐onset Atrial Fibrillation and Adverse Cardiovascular and Renal Events in Patients with Type 2 Diabetes Treated with Sodium‐glucose Co‐transporter‐2 Inhibitors by Yi‐Hsin Chan; Shao‐Wei Chen; Tze‐Fan Chao; Yi‐Wei Kao; Chien‐Ying Huang; Pao‐Hsien Chu is a Medicine article available to read on EtoBox.

What is Impact of the Initial Decline in Estimated Glomerular Filtration Rate on the Risk of New‐onset Atrial Fibrillation and Adverse Cardiovascular and Renal Events in Patients with Type 2 Diabetes Treated with Sodium‐glucose Co‐transporter‐2 Inhibitors about?

## Abstract ## Aim To investigate the impact of initial decline in estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes (T2D) following sodium‐glucose co‐transporter‐2 inhibitor (SGLT2i) treatment. ## Materials and Methods We used medical data from a multicentre healthcare provider in Taiwan and recruited 11 769 patients with T2D with baseline/follow‐up eGFR data available after 1 to 3 months of SGLT2i treatment from 1 June 2016 to 31 December 2018. Patients were followed up from the drug index date until the occurrence of adverse clinical events, SGLT2i discontinuation or the end of the study period, whichever took place first. ## Results Overall, SGLT2i treatment was associated with an initial eGFR decline of 3.5% ± 14.0% after a median treatment period of 10 weeks. A total of 37.1% (n = 4371) of patients experienced no eGFR decline, and 30.5% (n = 3593), 20.2% (n = 2376), 8.5% (n = 999) and 3.7% (n = 430) of patients experienced an eGFR decline of 0%‐10%, 10%‐20%, 20%‐30% and more than 30%, respectively. The mean eGFR over time became stable after 6 months in all eGFR decline categories, even in the group with a pronounced eGFR decline of more than 30%. C

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Author

Yi‐Hsin Chan; Shao‐Wei Chen; Tze‐Fan Chao; Yi‐Wei Kao; Chien‐Ying Huang; Pao‐Hsien Chu

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)