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Difference in prognosis between patients infected with hepatitis B virus with genotype B and those with genotype C in the Okinawa Islands: A prospective study by Tomokuni Nakayoshi; Tatsuji Maeshiro; Tomofumi Nakayoshi; Hiroki Nakasone; Hiroshi Sakugawa; Fukunori Kinjo; Etsuro Orito; Masashi Mizokami is a Medicine article available to read on EtoBox.
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## Abstract The factors contributing to the prognosis of hepatitis B virus (HBV)‐ related chronic liver disease were assessed prospectively in 72 patients with chronic hepatitis B confirmed clinically and pathologically. A comparative study was undertaken between patients infected with genotype B and those with genotype C. During the follow‐up period, 13 (81.3%) of 16 patients with genotype B who were initially hepatitis B e antigen (HBeAg) positive became HBeAg negative and 14 (51.9%) of 27 with genotype C became HBeAg negative. HBeAg had been cleared in 8 (61.5%) of 13 patients with genotype B within the first 2 years of the follow‐up, but in only one (7.1%) of 14 with genotype C (__P__ < 0.05). Four (11.4%) of 35 patients with genotype B had progressed to cirrhosis, whereas, 12 (32.4%) of 37 patients with genotype C progressed to cirrhosis, including two patients with hepatocellular carcinoma. Multivariate analysis showed that difference in HBV genotype influenced significantly either the clearance of HBeAg or the development of cirrhosis. In conclusion, HBeAg was cleared from sera more frequently and earlier in patients with genotype B compared with those with genotype C, and d
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- Author
- Tomokuni Nakayoshi; Tatsuji Maeshiro; Tomofumi Nakayoshi; Hiroki Nakasone; Hiroshi Sakugawa; Fukunori Kinjo; Etsuro Orito; Masashi Mizokami
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)