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Diagnostic Properties of Natriuretic Peptides and Opportunities for Personalized Thresholds for Detecting Heart Failure in Primary Care by Ralf E. Harskamp; Lukas De Clercq; Lieke Veelers; Martijn C. Schut; Henk C.P.M. van Weert; M. Louis Handoko; Eric P. Moll van Charante; Jelle C.L. Himmelreich is a Medicine article available to read on EtoBox.
What is Diagnostic Properties of Natriuretic Peptides and Opportunities for Personalized Thresholds for Detecting Heart Failure in Primary Care about?
## Abstract ## Objectives Heart failure (HF) is a prevalent syndrome with considerable disease burden, healthcare utilization and costs. Timely diagnosis is essential to improve outcomes. This study aimed to compare the diagnostic performance of B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) in detecting HF in primary care. Our second aim was to explore if personalized thresholds (using age, sex, or other readily available parameters) would further improve diagnostic accuracy over universal thresholds. ## Methods A retrospective study was performed among patients without prior HF who underwent natriuretic peptide (NP) testing in the Amsterdam General Practice Network between January 2011 and December 2021. HF incidence was based on registration out to 90 days after NP testing. Diagnostic accuracy was evaluated with AUROC, sensitivity and specificity based on guideline-recommended thresholds (125 ng/L for NT-proBNP and 35 ng/L for BNP). We used inverse probability of treatment weighting to adjust for confounding. ## Results A total of 15,234 patients underwent NP testing, 6,870 with BNP (4.5 % had HF), and 8,364 with NT-proBNP (5.7 % had HF). NT-proBNP was more a
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- Author
- Ralf E. Harskamp; Lukas De Clercq; Lieke Veelers; Martijn C. Schut; Henk C.P.M. van Weert; M. Louis Handoko; Eric P. Moll van Charante; Jelle C.L. Himmelreich
- Publisher
- Walter de Gruyter GmbH
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)