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Hybridomas Expressing γδ T‐Cell Receptors Respond to Cardiolipin and β~2~‐Glycoprotein 1 (Apolipoprotein H) by W. K. Born; M. Vollmer; C. Reardon; E. Matsuura; D. R. Voelker; P. C. Giclas; R. L. O'Brien is a Immunology and Microbiology article available to read on EtoBox.

What is Hybridomas Expressing γδ T‐Cell Receptors Respond to Cardiolipin and β~2~‐Glycoprotein 1 (Apolipoprotein H) about?

## Abstract Hybridomas expressing murine γδ T‐cell receptors were found to produce cytokines in response to cardiolipin (CL) and structurally related anionic phospholipids. This response required serum at concentrations related to the amount of CL in cultures. The purified serum factor, β~2~‐glycoprotein 1 (β~2~‐GP1) (apolipoprotein H), supported the CL response alone, whereas several other serum proteins and ovalbumin did not. β~2~‐GP1 is known to form complexes with anionic phospholipids, particularly CL, which are often recognized by pathological autoantibodies. We speculate that γδ T cells also recognize such complexes and that the hybridoma response reported here reflects this specificity.

Who reads Hybridomas Expressing γδ T‐Cell Receptors Respond to Cardiolipin and β~2~‐Glycoprotein 1 (Apolipoprotein H)?

Author

W. K. Born; M. Vollmer; C. Reardon; E. Matsuura; D. R. Voelker; P. C. Giclas; R. L. O'Brien

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0300-9475)

Published

2003

Language

EN

Field

Immunology and Microbiology (Life Sciences)