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Conjugated Linoleic Acids Inhibit Hypoxia Inducible Factor-1^|^alpha; Stabilization under Hypoxic Condition in Human Hepatocellular Carcinoma Cells by Masao Yamasaki; Taku Nagatomo; Tetsuya Matsuyama; Yuri Ikeho; Emiko Kato; Kei Nishiyama; Yoichi Sakakibara; Masahito Suiko; Kazuo Nishiyama is a Chemistry article available to read on EtoBox.
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## 1 Introduction Accumulating data strongly suggest that various fatty acids exert anti-cancer effects that can be attributed to their ability to induce apoptotic cell death, regulate the cell cycle, manipulate eicosanoid production, etc. [1][2][3] . Although such anti-cancer effects of fatty acids have been proven in animal models, detailed mechanisms still remain to be elucidated. In solid tumors, it is well known that hypoxic regions occur inside the tumors because of lack of O 2 supply from the surrounding blood vessels, and the adaptive response to hypoxia occurs in the tumor cells for survival and proliferation. Hypoxia-inducible factor (HIF) -1, a heterodimeric transcription factor composed of two subunits known as HIF-1α and HIF-1β, regulates cellular homeostasis in response to the cellular O 2 concentrations. Under normoxia (20% O 2 ) , HIF-1α is constitutively expressed, while prolines 402 and 546 in the HIF-1α protein are easily hydroxylated, leading to HIF-1α ubiquitination and proteasomal degradation. On the other hand, under hypoxic conditions, HIF-1α protein is stable, and it translo-
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It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Masao Yamasaki; Taku Nagatomo; Tetsuya Matsuyama; Yuri Ikeho; Emiko Kato; Kei Nishiyama; Yoichi Sakakibara; Masahito Suiko; Kazuo Nishiyama
- Publisher
- Japan Science and Technology Information Aggregator, Electronic; Japan Oil Chemists' Society; Japan Oil Chemists Society (ISSN 1345-8957)
- Published
- 2012
- Language
- EN
- Field
- Chemistry (Life Sciences)