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Gene-environment Interactions and the Effect on Obesity Risk in Low and Middle-income Countries: a Scoping Review by Sophia L. Pledger; Fariba Ahmadizar is a Medicine article available to read on EtoBox.

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## Background Obesity represents a major and preventable global health challenge as a complex disease and a modifiable risk factor for developing other non-communicable diseases. In recent years, obesity prevalence has risen more rapidly in low- and middle-income countries (LMICs) compared to high-income countries (HICs). Obesity traits are shown to be modulated by an interplay of genetic and environmental factors such as unhealthy diet and physical inactivity in studies from HICs focused on populations of European descent; however, genetic heterogeneity and environmental differences prevent the generalisation of study results to LMICs. Primary research investigating gene-environment interactions (GxE) on obesity in LMICs is limited but expanding. Synthesis of current research would provide an overview of the interactions between genetic variants and environmental factors that underlie the obesity epidemic and identify knowledge gaps for future studies. ## Methods Three databases were searched systematically using a combination of keywords such as “genes”, “obesity”, “LMIC”, “diet”, and “physical activity” to find all relevant observational studies published before November 2022. #

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Author

Sophia L. Pledger; Fariba Ahmadizar

Publisher

Frontiers Media SA

Published

2023

Field

Medicine (Health Sciences)