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Can I read The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma on EtoBox?
The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma by Robert Kammerer; Rainer Riesenberg; Christoph Weiler; Jens Lohrmann; Julia Schleypen; Wolfgang Zimmermann is a Medicine article available to read on EtoBox.
What is The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma about?
## Abstract __CEACAM1__ acts as a tumour suppressor in various epithelial tumours. On the other hand, __de novo__ expression of CEACAM1 is strongly associated with reduced disease‐free survival of melanoma and non‐small cell lung carcinoma patients. Since effector functions of natural killer and T cells are inhibited by homophilic CEACAM1 interaction, immune escape could be responsible for the poor prognosis of these patients. Here, we describe CEACAM1 expression in normal kidney, renal adenomas and renal cell carcinomas (RCC) using a novel antibody generated by genetic immunization. In normal kidney, CEACAM1 was found in epithelial cells of proximal tubules and in endothelial cells. In contrast, tumour cells of 30 clear cell, three chromophobic, and two chromophilic RCCs were completely devoid of CEACAM1. Renal adenomas also lacked CEACAM1 expression. Similarly, RCC cell lines CaKi1, CaKi2, A498, and RCC26 exhibited no or low‐level CEACAM1 expression. However, CEACAM1 expression was transiently induced in A498 cells upon contact with allogeneic CD8^+^ T cells, mediated at least in part by interferon‐γ. Furthermore, the majority of tumour‐infiltrating T and NK cells expressed CEACA
Who reads The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Robert Kammerer; Rainer Riesenberg; Christoph Weiler; Jens Lohrmann; Julia Schleypen; Wolfgang Zimmermann
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)