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An observational study of pro- and anti-angiogenic factors in hypertensive disorders of pregnancy in women of African ancestry by Nerolen Soobryan; Ajit Kumar; Jagidesa Moodley; Irene Mackraj is a Medicine article available to read on EtoBox.

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Hypertensive disorders in pregnancy (HDPs) are the leading cause of maternal and perinatal deaths worldwide. Despite the widely reported multisystemic pathophysiology of pre-eclampsia and other HDPs, it is unknown whether these disorders represent a continuum or separate entities making clinical diagnosis a challenge. This study aimed to investigate angiogenic, metabolic and immunoregulatory specific profiles of hypertensive and gestationally matched normotensive pregnancies. A total of 200 pregnancies from a regional hospital in South Africa, via convenience sampling, were quantitatively analysed for circulating sFlt-1; PlGF; VEGF; sENG; PAPP-A; PP13; ADAMTS 12; TGF-b1 in maternal serum samples using ELISA technique. Serum protein markers TGF-b1, sENG and PAPP-A were significantly increased (p < .05) in early-onset pre-eclampsia vs. NG1 groups. sFlt-1 was significantly higher in late-onset pre-eclampsia vs NG2 groups. The GH group showed a significant increase in TGF-b1 and PAPP-A vs. NG1 counterpart. ADAMTS12 and sENG were significantly lower in gestational hypertension vs. early-onset pre-eclampsia. No significant differences were seen in PlGF, VEGF and PP13 levels across the gr

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Author

Nerolen Soobryan; Ajit Kumar; Jagidesa Moodley; Irene Mackraj

Publisher

Informa UK Limited

Published

2022

Language

EN

Field

Medicine (Health Sciences)