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HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients by Aleksandra Stefanović; Jelena Kotur-Stevuljević; Slavica Spasić; Jelena Vekić; Aleksandra Zeljković; Vesna Spasojević-Kalimanovska; Zorana Jelić-Ivanović is a Medicine article available to read on EtoBox.

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Objectives: In this study we examined the relationship of oxidative stress and hyperglycaemia to antioxidative capacity of high-density cholesterol (HDL-C) particles in type 2 diabetes mellitus (DM). Design and methods: Oxidative stress status parameters (superoxide anion (O 2 -), superoxide dismutase (SOD) activity and paraoxonase (PON1) status were assessed in 114 patients with type 2 DM and 91 healthy subjects. HDL particle diameters were determined by non-denaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: Patients had significantly higher concentrations of oxidative stress parameter O 2 -(pb 0.001) and antioxidative defence, SOD activity (pb 0.001). Paraoxonase activity was significantly lower in diabetics (pb 0.001). The PON1 192 phenotype distribution among study groups was not significantly different. HDL 3 phenotype was significantly prevalent among patients (pb 0.001). Paraoxonase activity was significantly lower in patients with predominantly HDL 2 particles than in controls. Conclusions: The results of our current study indicate that the diabetic HDL 2 phenotype is associated with hyperglycaemia, lower PON1 activity and elevated oxidative stress.

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Author

Aleksandra Stefanović; Jelena Kotur-Stevuljević; Slavica Spasić; Jelena Vekić; Aleksandra Zeljković; Vesna Spasojević-Kalimanovska; Zorana Jelić-Ivanović

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-9120)

Published

2010

Language

EN

Field

Medicine (Health Sciences)