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Long‐term administration of oral macrolides for acne treatment increases macrolide‐resistant Propionibacterium acnes by Keisuke Nakase; Yuhei Okamoto; Sae Aoki; Norihisa Noguchi is a Medicine article available to read on EtoBox.

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## Abstract Macrolide‐resistant __Propionibacterium acnes__ are frequently isolated from patients with acne vulgaris, and the most resistant isolates (>90% resistance) have the 23S rRNA mutation. An increase in resistant __P. acnes__ with this mutation is thought to be caused by the inappropriate use of antimicrobials. Therefore, we studied the mutation frequency of macrolide resistance in __P. acnes in vitro__. When __P. acnes__ mutants were exposed to clarithromycin after being incubated in broth without antimicrobials, resistant mutants with the 23S rRNA mutation were not isolated. However, the mutants were obtained at the frequency of 10^−6^ after being pre‐incubated with 0.03 μg/mL of antimicrobials. This is the estimated epidermal concentration of clarithromycin after p.o. administration. The resistant mutants had the 23S rRNA mutations A2058G, A2059G and C2611G. When pre‐incubated with clarithromycin, C2611G mutants which showed resistance to clarithromycin were obtained 32.1% more often than pre‐incubated with clindamycin (__P__<0.01). By contrast, when pre‐incubated with clindamycin, A2058G mutants, which show high‐level resistance to both clarithromycin and clindamycin, w

Who reads Long‐term administration of oral macrolides for acne treatment increases macrolide‐resistant Propionibacterium acnes?

Author

Keisuke Nakase; Yuhei Okamoto; Sae Aoki; Norihisa Noguchi

Publisher

Wiley

Published

2017

Language

EN

Field

Medicine (Health Sciences)