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Can I read Additive Effect of Resveratrol on Astrocyte Swelling Post-exposure to Ammonia, Ischemia and Trauma In Vitro on EtoBox?

Additive Effect of Resveratrol on Astrocyte Swelling Post-exposure to Ammonia, Ischemia and Trauma In Vitro by Taherian, Mehran; Norenberg, Michael D.; Panickar, Kiran S.; Shamaladevi, Nagarajarao; Ahmad, Anis; Rahman, Purbasha; Jayakumar, Arumugam R. is a Neuroscience article available to read on EtoBox.

What is Additive Effect of Resveratrol on Astrocyte Swelling Post-exposure to Ammonia, Ischemia and Trauma In Vitro about?

Swelling of astrocytes represents a major component of the brain edema associated with many neurological conditions, including acute hepatic encephalopathy (AHE), traumatic brain injury (TBI) and ischemia. It has previously been reported that exposure of cultured astrocytes to ammonia (a factor strongly implicated in the pathogenesis of AHE), oxygen/glucose deprivation, or to direct mechanical trauma results in an increase in cell swelling. Since dietary polyphenols have been shown to exert a protective effect against cell injury, we examined whether resveratrol (RSV, 3,5,4'-trihydroxy-trans-stilbene, a stilbenoid phenol), has a protective effect on astrocyte swelling following its exposure to ammonia, oxygen-glucose deprivation (OGD), or trauma in vitro. Ammonia increased astrocyte swelling, and pre- or post-treatment of astrocytes with 10 and 25 μM RSV displayed an additive effect, while 5 μM did not prevent the effect of ammonia. However, pre-treatment of astrocytes with 25 μM RSV slightly, but significantly, reduced the trauma-induced astrocyte swelling at earlier time points (3 h), while post-treatment had no significant effect on the trauma-induced cell swelling at the 3 h ti

Who reads Additive Effect of Resveratrol on Astrocyte Swelling Post-exposure to Ammonia, Ischemia and Trauma In Vitro?

It is typically read by researchers, students, and practitioners in Neuroscience.

Author
Taherian, Mehran; Norenberg, Michael D.; Panickar, Kiran S.; Shamaladevi, Nagarajarao; Ahmad, Anis; Rahman, Purbasha; Jayakumar, Arumugam R.
Publisher
Springer; Springer-Verlag; Kluwer Academic/Plenum Publishers; Springer Science and Business Media LLC (ISSN 0364-3190)
Published
2020
Language
EN
Field
Neuroscience (Life Sciences)

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