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The Role of Induction Therapy for Sinonasal Cancers by Keonho A. Kong; Brian D. Thorp; Siddharth H. Sheth is a Medicine article available to read on EtoBox.

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Sinonasal cancer I Induction chemotherapy I Sinonasal squamous cell carcinoma I Sinonasal adenoid cystic carcinoma I Sinonasal undifferentiated carcinoma I Esthesioneuroblastoma ## Opinion statement The role of induction chemotherapy in sinonasal cancers is promising; however, prospective studies with higher grades of evidence are needed. With the currently available literature, the authors would advocate for the use of induction chemotherapy (IC) in locally advanced sinonasal squamous cell carcinoma (T3-T4) for organ preservation and potentially for improved survival outcomes. In sinonasal undifferentiated carcinoma (SNUC), IC should be considered in all patients given its tendency for aggressive invasion and poor outcomes. In SNUC, response to IC may direct the modality of definitive treatment to follow. In responders (partial or complete), chemoradiation therapy should be strongly considered. In non-responders or in those with progression of disease, surgical therapy is favored. For esthesioneuroblastoma, surgical resection with negative margins and adjuvant radiation therapy remains the gold standard. However, IC may be considered for locally advanced disease especially with or

Who reads The Role of Induction Therapy for Sinonasal Cancers?

Author

Keonho A. Kong; Brian D. Thorp; Siddharth H. Sheth

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)