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Clinical Significance of Serum and Ascitic P53 Autoantibodies in Epithelial Ovarian Carcinoma by Burghard Abendstein; Christian Marth; Elisabeth Müller-Holzner; Martin Widschwendter; Günter Daxenbichler; Alain G. Zeimet is a Medicine article available to read on EtoBox.
What is Clinical Significance of Serum and Ascitic P53 Autoantibodies in Epithelial Ovarian Carcinoma about?
## BACKGROUND. Accumulation of mutated p53 in malignant cells can lead to the generation of anti-p53 autoantibodies in the serum and other body fluids of cancer patients. This retrospective study was performed to evaluate the prognostic significance of preoperative serum and ascitic anti-p53 antibodies in advanced ovarian carcinoma. ## METHODS. In 113 ovarian carcinoma patients who presented with significant amounts of ascites, anti-p53 autoantibodies were determined by a highly specific enzyme-linked immunosorbent assay of blood and ascites. Disease free and overall survival of study patients was estimated by the product limit method of Kaplan and Meier. Differences in survival were examined according to criteria of Mantel and Breslow. A multiple regression analysis based on the Cox proportional hazards model was used to determine the independence of prognostic variables. ## RESULTS. Serum and ascitic anti-p53 antibodies were found in 28 (25%) and 21 (19%) of the study patients, respectively. In univariate analysis, detection of anti-p53 antibodies in ascites but not in serum was found to be a sign of unfavorable disease free survival (P Ͻ 0.003) and overall survival (P Ͻ 0.01). M
Who reads Clinical Significance of Serum and Ascitic P53 Autoantibodies in Epithelial Ovarian Carcinoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Burghard Abendstein; Christian Marth; Elisabeth Müller-Holzner; Martin Widschwendter; Günter Daxenbichler; Alain G. Zeimet
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)