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Evaluation of a visual interpretation method for tau‐PET with 18 F‐flortaucipir by Ida Sonni; Orit H. Lesman Segev; Suzanne L. Baker; Leonardo Iaccarino; Deniz Korman; Gil D. Rabinovici; William J. Jagust; Susan M. Landau; Renaud La Joie; for the Alzheimer's Disease Neuroimaging Initiative is a Medicine article available to read on EtoBox.
What is Evaluation of a visual interpretation method for tau‐PET with 18 F‐flortaucipir about?
## Abstract ## Introduction Positron emission tomography targeting tau (tau‐PET) is a promising diagnostic tool for the identification of Alzheimer's disease (AD). Currently available data rely on quantitative measures, and a visual interpretation method, critical for clinical translation, is needed. ## Methods We developed a visual interpretation method for ^18^F‐flortaucipir tau‐PET and tested it on 274 individuals (cognitively normal controls, patients with mild cognitive impairment [MCI], AD dementia, and non‐AD diagnoses). Two readers interpreted ^18^F‐flortaucipir PET using two complementary indices: a global visual score and a visual distribution pattern. ## Results Global visual scores were reliable, correlated with global cortical ^18^F‐flortaucipir standardized uptake value ratio (SUVR) and were associated with clinical diagnosis and amyloid status. The AD‐like ^18^F‐flortaucipir pattern had good sensitivity and specificity to identify amyloid‐positive patients with AD dementia or MCI. ## Discussion This ^18^F‐flortaucipir visual rating scheme is associated with SUVR quantification, clinical diagnosis, and amyloid status, and constitutes a promising approach to tau measur
Who reads Evaluation of a visual interpretation method for tau‐PET with 18 F‐flortaucipir?
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- Author
- Ida Sonni; Orit H. Lesman Segev; Suzanne L. Baker; Leonardo Iaccarino; Deniz Korman; Gil D. Rabinovici; William J. Jagust; Susan M. Landau; Renaud La Joie; for the Alzheimer's Disease Neuroimaging Initiative
- Publisher
- Elsevier ; Elsevier BV; [Philadelphia]: Elsevier Inc.; Wiley (ISSN 2352-8729)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)