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work in one coke oven plant and 16 males (referents) from an administrative area, were studied. Mean trans-anti-BaP-tetraol and 1-OHP concentrations (mean -4-standard deviation) were 0.4 + 0.3 nmol/ mol creatinine and 9.7 -4-21.6 ~m/mol creatinine, respectively, in coke oven workers. These concentrations were significantly higher than those in referents (0.03 + 0.03 nmol/mol creatinine, P <0.001 and 0.4 5: 0.2 p.mol/mol creatinine, P <0.01, respectively). Urinary trans-anti-BaP-tetraol concentrations were significantly and positive correlated with individual average BSF and urinary 1-OHP concentrations, i.e. the higher the urinary trans-anti-BaP-tetraol concentrations, the more ambient BSF exposure and urinary 1-OHP concentrations (Spearman correlation coefficients R = 0.68 and 0.70, respectively; P <0.0001; n = 57). Results suggested urinary 1-OHP and trans-anti-BaP-tetraol might be considered as potential biomarkers to assess uptake of known PAH carcinogens from air.

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Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0140-6701)

Published

2003

Language

EN

Field

Engineering (Physical Sciences)