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What is Overcoming Milling Issues in Y5 Antagonist Crystals about?

This study investigates the crystal forms of a Y5 receptor antagonist of neuropeptide Y, focusing on overcoming milling issues caused by exposed functional groups. Polymorphic screening revealed three crystal forms, with the hemihydrate form being processable while the stable form exhibited stiction during milling. The findings suggest that crystal conversion can address milling challenges in pharmaceutical manufacturing.

Author

Pramod Gatla

Language

EN