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Can I read Abzyme activity in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) on EtoBox?
Abzyme activity in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) by I.I. Generalov; E.V. Sydorskaya is a Immunology and Microbiology article available to read on EtoBox.
What is Abzyme activity in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) about?
MaWal and Methods: Various compounds were coinjected with the reporter antigens into the footpad of female BALB/c (wildtype, nu/+ or nu/nu) mice. Seven days later the number of TNP-specific AFC (IgGl) in suspensions of popliteal lymph nodes was measured wtth ELISPOT assay. In similarly treated mice, kinetics of of TNP-specific antibody titers were followed for 4-5 weeks. In the same mice, memory responses (DTH and specific antibodies) were measured 6 days after challenge with the reporter antigens alone. Reeuttez It was found that the autoimmunogens HgCls, phenytoin, nitrofurantoin and D-penicillamine and the allergens DNCB, TMA and tulipaline stimulated IgG1 production to both antigens, the macrophage activators incomplete Freund's adjuvant and silica and the irritants glutartc anhydride, CuCIp, and DMSC to TNP-CVA only, and hydroxyf-amino prccainamide to TNP-ficoll alone. The dtabetogen streptozotocin did not enhance IgGl production. but enhanced a cellular response (&Pa, CD8+ cells, IFNy) instead. Ethanol and acetone did not influence the responses. IgGl production to TNP-ficoll was locat, transient and did not always require T cell-help. In contrast, responses to TNP-OVA could
Who reads Abzyme activity in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- I.I. Generalov; E.V. Sydorskaya
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-2478)
- Published
- 1997
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)