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Quantitative magnetization transfer characteristics of the human cervical spinal cord in vivo: Application to Adrenomyeloneuropathy by Seth A. Smith; Xavier Golay; Ali Fatemi; Asif Mahmood; Gerald V. Raymond; Hugo W. Moser; Peter C.M. van Zijl; Greg J. Stanisz is a Medicine article available to read on EtoBox.
What is Quantitative magnetization transfer characteristics of the human cervical spinal cord in vivo: Application to Adrenomyeloneuropathy about?
## Abstract Magnetization transfer (MT) imaging has assessed myelin integrity in the brain and spinal cord; however, quantitative MT (qMT) has been confined to the brain or excised tissue. We characterized spinal cord tissue with qMT in vivo, and as a first application, qMT‐derived metrics were examined in adults with the genetic disorder Adrenomyeloneuropathy (AMN). AMN is a progressive disease marked by demyelination of the white matter tracts of the cervical spinal cord, and a disease in which conventional MRI has been limited. MT data were acquired at 1.5 Tesla using 10 radiofrequency offsets at one power in the cervical cord at C2 in 6 healthy volunteers and 9 AMN patients. The data were fit to a two‐pool MT model and the macromolecular fraction (M~ob~), macromolecular transverse relaxation time (T~2b~) and the rate of MT exchange (R) for lateral and dorsal column white matter and gray matter were calculated. M~ob~ for healthy volunteers was: WM = 13.9 ± 2.3%, GM = 7.9 ± 1.5%. In AMN, dorsal column M~ob~ was significantly decreased (__P__ < 0.03). T~2b~ for volunteers was: 9 ± 2 μs and the rate of MT exchange (R) was: WM = 56 ± 11 Hz, GM = 67 ± 12 Hz. Neither T~2b~ nor R showe
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- Author
- Seth A. Smith; Xavier Golay; Ali Fatemi; Asif Mahmood; Gerald V. Raymond; Hugo W. Moser; Peter C.M. van Zijl; Greg J. Stanisz
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)