Can I read Effects of Stress Associated with Academic Examination on the Kynurenine Pathway Profile in Healthy Students on EtoBox?

Effects of Stress Associated with Academic Examination on the Kynurenine Pathway Profile in Healthy Students by Kyaimon Myint; Kelly Jacobs; Aye Mu Myint; Sau Kuen Lam; Lyndal Henden; See Ziau Hoe; Gilles J. Guillemin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Effects of Stress Associated with Academic Examination on the Kynurenine Pathway Profile in Healthy Students about?

The effects of stress on the neuroendocrine, central nervous and immune systems are extremely complex. The kynurenine pathway (KP) of the tryptophan metabolism is recognised as a cross-link between the neuroendocrine- and immune systems. However, the effects of acute stress from everyday life on KP activation have not yet been studied. This study aims to investigate changes in the levels of the KP neuroactive metabolites and cytokines in response to stress triggered by academic examinations. Ninety-two healthy first year medical students benevolently participated in the study. Parameters were measured pre- examination, which is considered to be a high-stress period, and post-examination, as a low-stress period. Stress induced by academic examinations significantly increases the perceived stress scores (__p__<0.001), serum cortisol levels (__p__<0.001) and brain-derived neurotrophic factor (BDNF) levels (__p__<0.01). It decreased IL-10 levels (__p__<0.05) but had no effect on IL-6 and TNF-alpha levels. Only the KP neuroactive metabolite, 3-hydroxykynurenine (3-HK) significantly increased (__p__<0.01) in the post-examination period. In addition, the stress scores positively correlate

Who reads Effects of Stress Associated with Academic Examination on the Kynurenine Pathway Profile in Healthy Students?

Author

Kyaimon Myint; Kelly Jacobs; Aye Mu Myint; Sau Kuen Lam; Lyndal Henden; See Ziau Hoe; Gilles J. Guillemin

Publisher

Public Library of Science (PLoS)

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)