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TXNIP Suppresses the Osteochondrogenic Switch of Vascular Smooth Muscle Cells in Atherosclerosis by Sang-Ho Woo; Dongsoo Kyung; Seung Hyun Lee; Kyu Seong Park; Minkyu Kim; Kibyeong Kim; Hyo-Jung Kwon; Young-Suk Won; Inpyo Choi; Young-Jun Park; Du-Min Go; Jeong-Seop Oh; Won Kee Yoon; Seung Sam Paik; Ji Hyeon Kim; Yong-Hwan Kim; Jae-Hoon Choi; Dae-Yong Kim is a Medicine article available to read on EtoBox.
What is TXNIP Suppresses the Osteochondrogenic Switch of Vascular Smooth Muscle Cells in Atherosclerosis about?
## Background: The osteochondrogenic switch of vascular smooth muscle cells (VSMCs) is a pivotal cellular process in atherosclerotic calcification. However, the exact molecular mechanism of the osteochondrogenic transition of VSMCs remains to be elucidated. Here, we explore the regulatory role of TXNIP (thioredoxin-interacting protein) in the phenotypical transitioning of VSMCs toward osteochondrogenic cells responsible for atherosclerotic calcification. ## Methods: The atherosclerotic phenotypes of __Txnip__ ^-/-^ mice were analyzed in combination with single-cell RNA-sequencing. The atherosclerotic phenotypes of __Tagln__ -Cre; __Txnip__ ^flox/flox^ mice (smooth muscle cell-specific __Txnip__ ablation model), and the mice transplanted with the bone marrow of __Txnip__ ^-/-^ mice were analyzed. Public single-cell RNA-sequencing dataset (GSE159677) was reanalyzed to define the gene expression of TXNIP in human calcified atherosclerotic plaques. The effect of TXNIP suppression on the osteochondrogenic phenotypic changes in primary aortic VSMCs was analyzed. ## Results: Atherosclerotic lesions of __Txnip__ ^-/-^ mice presented significantly increased calcification and deposition of c
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- Author
- Sang-Ho Woo; Dongsoo Kyung; Seung Hyun Lee; Kyu Seong Park; Minkyu Kim; Kibyeong Kim; Hyo-Jung Kwon; Young-Suk Won; Inpyo Choi; Young-Jun Park; Du-Min Go; Jeong-Seop Oh; Won Kee Yoon; Seung Sam Paik; Ji Hyeon Kim; Yong-Hwan Kim; Jae-Hoon Choi; Dae-Yong Kim
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)