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Linkage Map of a Region of Human Chromosome Band 11Q13 Amplified in Breast and Squamous Cell Tumors by Sharon Brookes; G. Alistair Lammie; Clive Dickson; Gordon Peters; Ed Schuuring is a Medicine article available to read on EtoBox.

What is Linkage Map of a Region of Human Chromosome Band 11Q13 Amplified in Breast and Squamous Cell Tumors about?

DNA amplification involving markers on human chromosome band I I q I 3 is a consistent feature of several major cancers, notably adenocarcinoma of the breast and squamous cell carcinoma of the head, neck, lung, and esophagus. Since the presence of the amplification may be clinically significant, by defining a subset of patients at increased risk, it is important t o establish which of the several genes on the amplified DNA provides the selective force. Here we describe a physical map of the centromeric end of the amplified DNA as it exists in a particular squamous carcinoma cell line (UMSCC2) and establish an unambiguous order for several known markers in the region, including pMS5 I/D I I S97, pHB I59/D I I S 146, BCLI, PRAD I] D I I S287, HSTFIIFGF4 and INl2/FGF3. Significantly, PRAD I is within 120-1 50 kb of the BCLl translocation breakpoint and the data identify a new CpG island (D I IS8 14) between PRAD I and HSTFI. The ordering of the HSTFl and INT2 genes and the clustering of CpG islands in the region have important implications in assessing whether the frequently observed amplifications at I I q 13 are centered on one or more genes. Genes Chrorn Cancer 4:29@-301 (1992). 0

Who reads Linkage Map of a Region of Human Chromosome Band 11Q13 Amplified in Breast and Squamous Cell Tumors?

Author

Sharon Brookes; G. Alistair Lammie; Clive Dickson; Gordon Peters; Ed Schuuring

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)

Published

1992

Language

EN

Field

Medicine (Life Sciences)