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Can I read Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691 on EtoBox?
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691 by Khaled A. Shaaban; Sherif I. Elshahawi; Xiachang Wang; Jamie Horn; Madan K. Kharel; Markos Leggas; Jon S. Thorson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691 about?
Actinomadura melliaura ATCC 39691, a strain isolated from a soil sample collected in Bristol Cove, California, is a known producer of the disaccharide-substituted AT2433 indolocarbazoles (6−9). Reinvestigation of this strain using new media conditions led to >40-fold improvement in the production of previously reported AT2433 metabolites and the isolation and structure elucidation of the four new analogues, AT2433-A3, A4, A5, and B3 (1−4). The availability of this broader set of compounds enabled a subsequent small antibacterial/fungal/cancer SAR study that revealed disaccharyl substitution, N-6 methylation, and C-11 chlorination as key modulators of bioactivity. The slightly improved anticancer potency of the newly reported N-6-desmethyl 1 (compared to 6) contrasts extensive SAR of monoglycosylated rebeccamycin-type topoisomerase I inhibitors where N-6 alkylation has contributed to improved potency and ADME. Complete 2D NMR assignments for the known metabolite BMY-41219 (5) and 13 C NMR spectroscopic data for the known analogue AT2433-B1 (7) are also provided for the first time.
Who reads Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Khaled A. Shaaban; Sherif I. Elshahawi; Xiachang Wang; Jamie Horn; Madan K. Kharel; Markos Leggas; Jon S. Thorson
- Publisher
- American Chemical Society (ACS)
- Published
- 2015
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)