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Effects of Bisphosphonates to Treat Osteoporosis in Children with Cerebral Palsy: a Meta-analysis by Min Jeong Kim; Soo-Nyung Kim; In-Sik Lee; Sochung Chung; Joonchul Lee; YouNa Yang; Inho Lee; Seong-Eun Koh is a Medicine article available to read on EtoBox.

What is Effects of Bisphosphonates to Treat Osteoporosis in Children with Cerebral Palsy: a Meta-analysis about?

## Background: In childhood and adolescence, some patients with cerebral palsy (CP) have long-term limited mobility, which can lead to secondary osteoporosis, Prevention and treatment strategies have been evaluated for the management of low bone mineral density (BMD) and fragility fractures. Currently, however, there are no established guidelines for the stratification and individualization of therapeutic interventions. Recently, an increasing number of studies have reported on the use of bisphosphonates to increase BMD in various pediatric conditions, and bisphosphonates have been suggested as a method to treat osteoporosis and prevent fractures. Purpose: We performed the current meta-analysis to assess the effects of bisphosphonates on increasing BMD in children who have CP with secondary osteoporosis. Materials and methods: A search of PubMed, Cochrane, and Embase from inception to April 2014 was performed with the following keywords: (bone disease, metabolic OR osteoporosis OR osteopenia) AND (child OR pediatric OR adolescent) AND (cerebral palsy) AND (bisphosphonate). Four studies were ultimately included in the meta-analysis: one randomized, double-blinded, placebo-controlled

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Author

Min Jeong Kim; Soo-Nyung Kim; In-Sik Lee; Sochung Chung; Joonchul Lee; YouNa Yang; Inho Lee; Seong-Eun Koh

Publisher

Walter de Gruyter GmbH

Published

2015

Language

EN

Field

Medicine (Health Sciences)