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Endothelin-1 Precursor Peptides Correlate with Severity of Disease and Outcome in Patients with Community Acquired Pneumonia by Philipp Schuetz; Daiana Stolz; Beat Mueller; Nils G Morgenthaler; Joachim Struck; Christian Mueller; Roland Bingisser; Michael Tamm; Mirjam Christ-Crain is a Medicine article available to read on EtoBox.

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## Background Circulating levels of endothelin-1 are increased in sepsis and correlate with severity of disease. A rapid and easy immunoassay has been developed to measure the more stable ET-1 precursor peptides proET-1. The objective of this study was to assess the diagnostic and prognostic value of proET-1 in a prospective cohort of mainly septic patients with community-acquired pneumonia. ## Methods We evaluated 281 consecutive patients with community acquired pneumonia. Serum proET-1 plasma levels were measured using a new sandwich immunoassay. ## Results ProET-1 levels exhibited a gradual increase depending on the clinical severity of pneumonia as assessed by the pneumonia severity index (PSI) and the CURB65 scores (p < 0.001 and p < 0.01). The diagnostic accuracy to predict bacteraemia of procalcitonin (AUC 0.84 [95% 0.74–0.93]) was superior than C-reactive protein (AUC 0.67 [95%CI 0.56–0.78]) and leukocyte count (AUC 0.66 [95%CI 0.55–0.78]) and in the range of proET-1(AUC of 0.77 [95%CI 0.67–0.86]). ProET-1 levels on admission were increased in patients with adverse medical outcomes including death and need for ICU admission. ROC curve analysis to predict the risk for mortal

Who reads Endothelin-1 Precursor Peptides Correlate with Severity of Disease and Outcome in Patients with Community Acquired Pneumonia?

Author

Philipp Schuetz; Daiana Stolz; Beat Mueller; Nils G Morgenthaler; Joachim Struck; Christian Mueller; Roland Bingisser; Michael Tamm; Mirjam Christ-Crain

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2334)

Published

2008

Language

EN

Field

Medicine (Health Sciences)