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Adverse Effects of Iron Deficiency Anemia on Pregnancy Outcome and Offspring Development and Intervention of Three Iron Supplements by Zhang, Qi (author);Lu, Xiao-Min (author);Zhang, Min (author);Yang, Chen-Ying (author);Lv, Si-Yuan (author);Li, Shi-Fen (author);Zhong, Cai-Yun (author);Geng, Shan-Shan (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Iron deficiency anemia (IDA) is a common micronutrient deficiency among pregnant women with severe consequences including impaired immuno-inflammatory system, premature birth, fetal death etc. The present study aimed to investigate the effects of three iron supplements on IDA female rats and their offspring. The IDA female rat model was established with low iron diet and the rats were then mated. After pregnancy, rats were fed diets containing different iron supplements (iron polysaccharide complex, iron protein succinylate and ferrous sulfate) until their offspring were 42 days old. Pregnancy outcomes, haematological, iron metabolism, physical and neurological development indexes were determined. The results showed that all three iron supplements improved the levels of hematological parameters of both mother and offspring rats. After iron supplementation, serum iron, transferrin saturation and serum ferritin levels were increased compared with the IDA group. The level of ferritin light chain in the liver and spleen of both mother and offspring rats in iron supplemented groups was significantly higher than that of the IDA group. The average number of born alive per litt

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Author

Zhang, Qi (author);Lu, Xiao-Min (author);Zhang, Min (author);Yang, Chen-Ying (author);Lv, Si-Yuan (author);Li, Shi-Fen (author);Zhong, Cai-Yun (author);Geng, Shan-Shan (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)