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Overexpression of cholesterol transporter StAR increasesIn Vivo rates of bile acid synthesis in the rat and mouse by Shunlin Ren; Phillip B. Hylemon; Dalila Marques; Emily Gurley; Patricia Bodhan; Elizabeth Hall; Kaye Redford; Gregorio Gil; William M. Pandak M.D. is a Medicine article available to read on EtoBox.
What is Overexpression of cholesterol transporter StAR increasesIn Vivo rates of bile acid synthesis in the rat and mouse about?
Bile acid synthesis (BAS) occurs mainly via two pathways: the "neutral" pathway, which is initiated by highly regulated microsomal CYP7A1, and an "acidic" pathway, which is initiated by mitochondrial CYP27A1. Previously, we have shown that overexpression of the steroidogenic acute regulatory protein (StAR), a mitochondrial cholesterol transport protein, increases bile acid biosynthesis more than 5-fold via the acidic pathway in primary rat hepatocytes. This observation suggests that mitochondrial cholesterol transport is the ratelimiting step of BAS via this pathway. The objective of this study was to determine the effect of increased StAR on rates of BAS in viva Overexpression of StAR and CYP7A1 were mediated via infection with recombinant adenoviruses. BAS rates were determined in chronic biliary-diverted rats and mice, and in mice with an intact enterohepatic circulation. The proteidmessenger RNA levels of StAR and CYP7A1 increased dramatically following overexpression. Overexpression of StAR or CYP7A1 led to a similar 2-fold (P < .01) increase in BAS over up-regulated (approximately 2-fold) 3-day chronic biliary-diverted control rats. Additionally, overexpression of StAR led to
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- Author
- Shunlin Ren; Phillip B. Hylemon; Dalila Marques; Emily Gurley; Patricia Bodhan; Elizabeth Hall; Kaye Redford; Gregorio Gil; William M. Pandak M.D.
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)