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Genetic Polymorphisms of the Renin-angiotensin System and the Outcome of Focal Segmental Glomerulosclerosis in Children by Yaacov Frishberg; Rachel Becker-Cohen; David Halle; Elad Feigin; Bella Eisenstein; Raphael Halevy; Danny Lotan; Isam Juabeh; Nathan Ish-Shalom; Daniella Magen; Yigal Shvil; Levana Sinai-Treiman; Alfred Drukker is a Medicine article available to read on EtoBox.
What is Genetic Polymorphisms of the Renin-angiotensin System and the Outcome of Focal Segmental Glomerulosclerosis in Children about?
## Background: The clinical course of primary focal segmental glomerulosclerosis (fsgs) in children is variable, with some patients having a much more rapidly progressing course than others. the purpose of our study was to compare the frequency of three polymorphisms of the renin-angiotensin system (ras) in children with fsgs with that in healthy controls of matching ethnic groups, and to determine whether the clinical outcome of fsgs was associated with different ras genotypes. ## Methods: Three ras genotypes were examined in 47 jewish and arab children with biopsy-proven primary fsgs and in a large control group: the ace insertion/deletion polymorphism in intron 16, the m235t mutation in the angiotensinogen gene, and the a1166c in the angiotensin ii type 1 receptor gene (at1r). ## Results: Arab patients showed a greater tendency towards progressive renal disease than their jewish counterparts (12 of 21 vs. 9 of 26, p = 0.05) and were less likely to achieve remission (3 of 21 vs. 11 of 26, p < 0.04), despite similar clinical presentation, medical management and follow-up. the ras allele prevalence was similar among patients and controls of matching ethnic backgrounds, and no diffe
Who reads Genetic Polymorphisms of the Renin-angiotensin System and the Outcome of Focal Segmental Glomerulosclerosis in Children?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Yaacov Frishberg; Rachel Becker-Cohen; David Halle; Elad Feigin; Bella Eisenstein; Raphael Halevy; Danny Lotan; Isam Juabeh; Nathan Ish-Shalom; Daniella Magen; Yigal Shvil; Levana Sinai-Treiman; Alfred Drukker
- Publisher
- Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; ScienceOpen (ISSN 0085-2538)
- Published
- 1998
- Language
- EN
- Field
- Medicine (Health Sciences)