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This paper describes a novel method for synthesizing two cyclic peptides called anabaenopeptins. The method uses an oxime resin to enable an acid-catalyzed head-to-side-chain cyclization/cleavage reaction. This allows rapid access to the anabaenopeptin scaffold by combining solid-phase and solution-phase synthesis. Specifically, the method orthogonally protects amino acids, elongates the linear peptide chain on resin, inserts D-lysine to enable selective deprotection, and uses the free epsilon-amino group t

Author

syed aftab hussain

Language

EN