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Synthesis and characterization of temperature responsive graft copolymers of dextran with poly(N-isopropylacrylamide) by Li-Qun Wang; Kehua Tu; Yuping Li; Jie Zhang; Liming Jiang; Zhihua Zhang is a Materials Science article available to read on EtoBox.

What is Synthesis and characterization of temperature responsive graft copolymers of dextran with poly(N-isopropylacrylamide) about?

Poly (N-isopropylacrylamide) (PNIPAAm) was grafted to dextran using ceric ion as redox initiator. The graft copolymers formed temperature responsive materials and can be used to construct polymeric micelles as drug carriers for colon-site 1 1 3 specifically delivery. The chemical structure of the graft copolymers was characterized by FTIR, H-and C-NMR spectroscopy. The influence of reaction conditions on the grafting parameters was investigated. It was found that the percentage of homopolymer formation (H%), the grafting efficiency (GE%) and the grafting (G%) of the copolymers increased with increasing the amount of the ceric catalyst used. Extension of the duration of graft reaction increased GE% and G% of the copolymers, suggesting that G% of the copolymers could be readily manipulated by changing copolymerization duration. Higher grafting temperature was in favor of increasing GE% and G%, however, when the reaction temperature was above the LCST of the copolymers, GE% and G% decreased. The optical transmittance of the copolymers in the aqueous solution was examined by UV-Vis instrument. The result showed that the phase transition of the graft copolymer in aqueous solution moved

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Author

Li-Qun Wang; Kehua Tu; Yuping Li; Jie Zhang; Liming Jiang; Zhihua Zhang

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1381-5148)

Published

2002

Language

EN

Field

Materials Science (Physical Sciences)